Veterinary Medicine Spectinomycin Hydrochloride/HCL Powder

Spectinomycin is an aminocyclitol antibiotic produced by S. spectabilis that is active against Gram-negative and Gram-positive bacteria. Spectinomycin inhibits protein synthesis by binding to the 30S ribosomal subunit and interfering with peptidyl tRNA translocation. Mutations in the gene for ribosomal protein S5 prevents binding of spectinomycin and contributes to bacterial resistance.

Spectinomycin dihydrochloride pentahydrate is an aminocylcitol antibiotic which is closely related to the aminoglycosides. Gram-positive and gram-negative Gonococcus spp. are reported to exhibit susceptibility to Spectinomycin. Studies indicate that Spectinomycin interferes with peptidyl tRNA translocation thereby affecting protein synthesis in susceptible bacteria. Additional reports note that mutations in ribosomal proteins may prevent the binding of spectinomycin, thus potentially confering resistence to the compound. Additionally, Eschericia coli is reported to be reversibly inhibited during growth and division by Spectinomycin and that variations in bacterial sensitivity may be mediated by differences in ribosomes among different E. coli mutants.

Spectinomycin dihydrochloride pentahydrate An aminocylcitol antibiotic , Pharmaceutical raw materials

 · Storage: Stored in dry and cool place, keep away from strong light and heat.

 · Shelf Life: Two years when properly stored.